1.9.1 Drugs affecting biliary composition and flow

Ursodeoxycholic acid
  • Cholurso® tablets 250mg (£16.80 = 2 x 250mg (500mg) daily)
  • SuspensionSF 250mg/5ml (£30.22 = 500mg daily)
  • Tablets 150mg, 300mg (£26.63 = 450mg daily)

Indications and dose

  • Dissolution of gallstones
    • 8–12mg/kg daily as a single dose at bedtime or in two divided doses, for up to 2 years; treatment is continued for 3–4 months after stones dissolve
  • Primary biliary cirrhosis
    • 12–16mg/kg daily in 3 divided doses for 3 months, then 12–16mg/kg once daily at bedtime
Obeticholic acid
  • Tablets 5mg, 10mg

Notes

  1. NICE TA443 Obeticholic acid for treating primary biliary cholangitis (April 2017) (NHS England Commissioned)

 

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