If a patient on any pancreatin preparation develops new abdominal symptoms (or any change in existing abdominal symptoms) the patient should be reviewed to exclude the possibility of colonic damage.
Creon
(Pancreatin)
- Capsules containing gastro-resistant granules 10,000 (£12.93 = 100 capsules)
- Amylase 8,000 unit
- Lipase 10,000 unit
- Protease 600 unit
- Capsules containing gastro-resistant granules 25,000 (£28.25 = 100 capsules)
- Amylase 18,000 unit
- Lipase 25,000 unit
- Protease 1,000 unit
Indications
- For the treatment of pancreatic exocrine insufficiency
Dose
- Adults and children (over 2 years): Initially 1-2 capsules to be taken with each meal either whole or contents mixed with acidic fluid or soft food (then swallowed immediately without chewing)
Notes
- If opening the capsules for administration, granules mixed with fluid or food should be taken immediately and the mixture not stored
- Do not crush or chew granules
Pancrex V
(Pancreatin)
- Powder (£246.40 = 300g container)
- Amylase 30,000 unit per gram powder
- Lipase 25,000 unit per gram powder
- Protease 1,400 unit per gram powder
Indications
- For the treatment of pancreatic exocrine insufficiency in patients requiring enteral feeding
Dose
- Adults and children: 0.5 - 2 grams swallowed dry or mixed with a little water or milk before each snack or meal
- New-born infants: 0.25 - 0.5 grams with each feed
Notes
- Pancrex V powder may be administered via a nasogastric tube or a gastrostomy tube
- Where enteral feeding is no longer required, patients should be reviewed to consider a switch to Creon capsules for ongoing treatment
- 1 gram of powder corresponds approximately to the volume of a 1.25 ml spoonful
- 2 grams of powder correspond approximately to the volume of a 2.5 ml spoonful