1.9.4 Pancreatin

If a patient on any pancreatin preparation develops new abdominal symptoms (or any change in existing abdominal symptoms) the patient should be reviewed to exclude the possibility of colonic damage.

Creon®

(Pancreatin)

  • Capsules containing gastro-resistant granules 10,000 (£12.93 = 100 capsules)
    • Amylase 8,000 unit
    • Lipase 10,000 unit
    • Protease 600 unit
  • Capsules containing gastro-resistant granules 25,000 (£28.25 = 100 capsules)
    • Amylase 18,000 unit
    • Lipase 25,000 unit
    • Protease 1,000 unit

Indications

  • For the treatment of pancreatic exocrine insufficiency

Dose

  • Adults and children (over 2 years): Initially 1-2 capsules to be taken with each meal either whole or contents mixed with acidic fluid or soft food (then swallowed immediately without chewing)

Notes

  1. If opening the capsules for administration, granules mixed with fluid or food should be taken immediately and the mixture not stored
  2. Do not crush or chew granules
Pancrex® V

(Pancreatin)

  • Powder (£224.00 = 300g container)
    • Amylase 30,000 unit per gram powder
    • Lipase 25,000 unit per gram powder
    • Protease 1,400 unit per gram powder

Indications

  • For the treatment of pancreatic exocrine insufficiency in patients requiring enteral feeding

Dose

  • Adults and children: 0.5 - 2 grams swallowed dry or mixed with a little water or milk before each snack or meal
  • New-born infants: 0.25 - 0.5 grams with each feed

Notes

  1. Pancrex V powder may be administered via a nasogastric tube or a gastrostomy tube
  2. Where enteral feeding is no longer required, patients should be reviewed to consider a switch to Creon capsules for ongoing treatment
  3. 1 gram of powder corresponds approximately to the volume of a 1.25 ml spoonful
  4. 2 grams of powder correspond approximately to the volume of a 2.5 ml spoonful
Last updated: 18-02-2022

 

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