13.3 Topical local anaesthetics and antipruritics

An emollient may be of value where the pruritus is associated with dry skin.

Antihistamines: A non-sedating antihistamine may be of some value in relieving severe itching or urticaria associated with eczema. A sedating antihistamine can be used if itching causes sleep disturbance (see section 3.4.1). Fexofenadine has been added for the treatment of chronic idiopathic urticaria in patients not adequately treated with cetirizine (see section 3.4.1).

Crotamiton dries skin, and is therefore not suitable for use in eczema. Lotion appears to be more soothing than cream.

Calamine preparations are often ineffective and have little proven benefit. In addition they dry the skin and cause the pruritus to worsen.

  • Cream 10% (£4.35 = 100g)



  • Apply two or three times a day.


  1. Exclude scabies before use as crotamiton masks this and it is not fully effective as an acaricide.
Levomenthol Cream, BP (Menthol in Aqueous Cream)
  • Cream 1% (£3.97 = 100g)
  • Cream (£11.70 = 30g)



  • Apply three or four times a day.
  1. Use for localised areas of itch (e.g. pruritus ani) rather than generalised itching.


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