4.9.2 Antimuscarinic drugs used in parkinsonism

Antimuscarinic drugs are less effective than levodopa for idiopathic Parkinson's disease. They may be used initially, either alone or with selegiline, in mild disease if tremor predominates. They also reduce symptoms of drug induced parkinsonism but should not be used prophylactically. Tardive dyskinesia is not improved and may be worsened by antimuscarinic drugs.

Orphenadrine
  • Tablets 50mg
  • Oral solution 50mg/5ml (£35.65 = 150ml)
Procyclidine
  • Tablets 5mg (£12.24 = 28)
  • Injection 5mg/ml (£14.50 per ampoule)
  • Syrup 2.5mg/5ml, 5mg/5ml (£11.54 = 150ml, 5mg/5ml)
Trihexyphenidyl
  • Tablets 2mg, 5mg (£17.91 = 5mg x 84 tablets)
  • Syrup 5mg/5ml (£20.00 = 200ml)

 

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