1.2 Antispasmodics and other drugs altering gut motility

Antimuscarinics

Hyoscine butylbromide
  • Tablets 10mg (£12.00 = 20mg four times daily)
  • Solution for injection 20mg in 1ml (£0.29 = 1ml ampoule)

Indications

Notes

  1. MHRA Drug Safety Update (February 2017) Hyoscine butylbromide injection: risk of serious adverse effects in patients with underlying cardiac disease:
    1. hyoscine butylbromide injection can cause serious adverse effects including tachycardia, hypotension, and anaphylaxis
    2. these adverse effects can result in a fatal outcome in patients with underlying cardiac disease, such as those with heart failure, coronary heart disease, cardiac arrhythmia, or hypertension
    3. hyoscine butylbromide injection should be used with caution in patients with cardiac disease
    4. monitor these patients, and ensure that resuscitation equipment, and personnel who are trained how to use this equipment, are readily available
    5. hyoscine butylbromide injection remains contraindicated in patients with tachycardia

Antispasmodics

Mebeverine
  • Tablets 135mg (£5.90 = 135mg three times daily)

Indications

Dose

  • 135mg three times daily
Peppermint oil
  • Gastro-resistant capsules 0.2ml (£7.04 - £14.08)

Indications

Dose

  • 1–2 capsules, swallowed whole with water, 3 times daily

Notes

  1. Avoid peppermint oil in patients with hiatus hernia or reflux. Peppermint oil may cause rectal stinging.
  2. Mintec capsules should not be taken by patients with a history of allergy to aspirin or aspirin-like products

Antipropulsives

Eluxadoline
  • Tablets 75mg, 100mg

Notes

  1. NICE TA471: Eluxadoline for treating irritable bowel syndrome with diarrhoea (August 2017)

 

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