3.3.2 Leukotriene receptor antagonists (LTRAs)
Patients in whom leukotriene receptor antagonists (LTRAs) may be particularly effective are those with aspirin sensitivity, a large exercise induced component to the symptoms, highly atopic eczema, and rhinitis.
Montelukast
- Tablets 10mg (£1.42)
- Chewable tablets sugar free 4mg, 5mg (£1.02 = 4mg, £1.08 = 5mg)
- Granules sachets sugar free 4mg (£6.23)
Indications and dose:
- Prophylaxis of asthma:
- Child 6 months–5 years: 4 mg once daily, dose to be taken in the evening.
- Child 6–14 years: 5 mg once daily, dose to be taken in the evening.
- Adults and adolescents 15 years of age and above: 10 mg once daily, dose to be taken in the evening.
Notes
- Montelukast is not indicated for treatment of an acute deterioration of asthma and should not be used to relieve an attack of acute severe asthma. Montelukast does not necessarily allow a reduction in the existing corticosteroid treatment.
- Montelukast may be considered if exercise induced asthma is a specific problem in a patient who is otherwise well controlled.
- Treatment should be trialled – if no benefit seen after 4 weeks, montelukast should be discontinued and alternative treatment options discussed with the patient.
- Refer to paediatric and adult asthma guidance for further information on the use of montelukast in the management of asthmatic patients.
- MHRA Drug Safety Update (September 2019): reminder of the risk of neuropsychiatric reactions
- be alert for neuropsychiatric reactions in patients taking montelukast; events have been reported in adults, adolescents, and children
- advise patients and their caregivers to read carefully the list of neuropsychiatric reactions in the patient information leaflet and seek medical advice immediately should they occur
- evaluate carefully the risks and benefits of continuing treatment if neuropsychiatric reactions occur
- be aware of newly recognised neuropsychiatric reactions of speech impairment (stuttering) and obsessive–compulsive symptoms.
3.3.3 Phosphodiesterase type-4 inhibitors
Roflumilast
- Tablets 250 micrograms, 500 micrograms
Notes
- NICE TA461: Roflumilast (Daxas), as an add-on to bronchodilator therapy, is recommended as an option for treating severe chronic obstructive pulmonary disease in adults with chronic bronchitis (July 2017), only if:
- the disease is severe, defined as a forced expiratory volume in 1 second (FEV1) after a bronchodilator of less than 50% of predicted normal, and
- the person has had 2 or more exacerbations in the previous 12 months despite triple inhaled therapy with a long-acting muscarinic antagonist, a long-acting beta-2 agonist and an inhaled corticosteroid.
- Treatment with roflumilast should be started by a specialist in respiratory medicine.