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Prescribing by brand is recommended for oral formulations due to variations in bioavailability.
There are significant drug interactions with theophylline / aminophylline. Consult the BNF, manufacturer's Summary of Product Characteristics (SPC) and specialist textbooks for further information.
Therapeutic levels of plasma-theophylline are usually between 10–20mg/litre (55–110micromol/litre), although lower concentrations may be effective in order to achieve satisfactory bronchodilation. Adverse effects can occur within the range 10–20mg/litre and both the frequency and severity increase at concentrations above 20mg/litre.
(Theophylline)
Indications
Dose
Notes
Notes