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8.5 Targeted antineoplastics
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8.5.1 Epidermal growth factor receptor (EGFR) inhibitors
8.5.2 Human epidermal growth factor receptor (HER2) inhibitors
8.5.3 Histone deacetylase (HDAC) inhibitors
8.5.4 Immunomodulatory agents (IMiDs)
8.5.5 Mammalian target of rapamycin (mTOR) inhibitors
8.5.6 Mitogen-activated protein kinase (MAPK) inhibitors
8.5.7 Mitotic inhibitors
8.5.8 Monoclonal antibodies
8.5.9 Multikinase inhibitors
8.5.10 Proteasome inhibitors
8.5.11 Retinoids
8.5.12 Tyrosine kinase inhibitors
8.5.13 VEGF / VEGFR inhibitors
Chapter 8: Immunomodulatory treatments and malignant disease
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Patients on chemotherapy at home
The Cancer Drugs Fund (CDF)
8.1 Selective internal radiation therapy (SIRT)
8.2 Drugs affecting the immune response
8.3 Sex hormones and hormone antagonists in malignant disease
8.4 Cytotoxic antineoplastics
8.5 Targeted antineoplastics
8.6 Miscellaneous antineoplastics
Page last updated:
8 December 2021
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8.5.11 Retinoids
First Line
Second Line
Specialist
Hospital Only
Oral retinoids
Tretinoin
- Capsules 10mg
Notes
- MHRA Drug Safety Update (June 2019): Oral retinoid medicines: revised and simplified pregnancy prevention educational materials for healthcare professionals and women, and advice about the risk of neuropsychiatric reactions.
- Tretinoin does not have a Pregnancy Prevention Programme in light of the oncology indication and specialist care setting. However, it is extremely teratogenic and the Summary of Product Characteristics (SPC) should be consulted for contraceptive and pregnancy testing requirements in female patients at risk of pregnancy.
- See resources for: contraception for drugs with teratogenic potential, and prescribing in pregnancy and lactation.
