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Referral
Neutropenia
Scope
- Often discovered as an incidental finding in a routine full blood count.
- The normal lower level is influenced by a person's race. The widely accepted lower level of 2 x 109/L is appropriate for Caucasians, but levels of 1.5 x 109/L or even lower may be normal for other ethnic groups.
Signs and Symptoms
Causes
- Infections - particularly viral (including human immunodeficiency virus (HIV)), also malaria, typhoid, TB. Acute changes are often noted within 1 to 2 days of infection and may persist for several weeks
- Drugs - neutropenia with antipsychotic medication has been a significant problem in recent years
- Autoimmune disease – isolated autoimmune neutropenia or in association with systemic lupus erythematosus (SLE) or rheumatoid arthritis
- Nutritional - B12 deficiency, folate deficiency, alcohol dependency, anorexia nervosa
- Splenomegaly
- Bone marrow pathology e.g. leukaemia, myelodysplasia, aplastic anaemia, bone marrow infiltration
History and Examination
History
- Frequency and severity of infections
- Mouth ulcers
- Recent viral illness
- Exposure to drugs and toxins
- Symptoms of malabsorption
- Symptoms suggesting reduced immunity
- Consider that many drugs can induce neutropenia. Most important are antipsychotics, anticonvulsants, and antithyroid drugs
Drug-induced neutropenia
- Anti-inflammatory drugs e.g., aminopyrine, phenylbutazone, salazopyrine
- Anti-bacterial drugs e.g, chloramphenicol, co-trimoxazole, sulfasalazine, penicillins
- Anticonvulsants e.g., phenytoin, carbamazepine
- Antithyroids e.g., carbimazole
- Phenothiazines e.g., chlorpromazine, thioridazine
- Psychotropics and antidepressants e.g., clozapine, mianserin, imipramine
- Many others including gold, penicillamine, mepacrine, amodiaquine, ticlopidine, tolbutamide and some herbal remedies
- Cytotoxic agents, including radiation
Examination
- Mouth ulcers
- Fever
- Signs of infection
- Jaundice
- Lymphadenopathy
- Hepatomegaly
- Splenomegaly
- Signs of autoimmune or connective tissue disorders
Neutropenia can be associated with life threatening infection. It is most significant when the total neutrophil count is less than 0.5 x 109/L.
FBC – look at haemoglobin, platelets, and blood film.
Determine the type of neutropenia for management:
| Classification | Neutrophil Count |
| Mild | 1.0 - 2.0 x 10 9/L |
| Moderate | > 0.5 < 1.0 x 10 9/L |
| Severe | < 0.5 x 10 9/L |
In persistent, moderate neutropenia without an obvious cause, consider other tests.
Other Tests
- Anti-nuclear antibodies (ANA)
- Rheumatoid factor
- B12 and folate
- Serum protein electrophoresis (SPE)
- HIV serology
- Liver enzymes
- Hepatitis B serology
Neutrophils less than 1.0 x 109/L
- Risk of significant bacterial infection increases when neutrophils less than 1.0 x 109/L, but more significant if less than 0.5 x 109/L.
- If unwell or fever, arrange urgent referral.
If well and afebrile:
- advise patient to seek medical attention if they become unwell or febrile
- repeat FBC in 48 hours. If neutropenia remains less than 1.0 x 109/L, discuss with a haematologist
Neutrophils 1.0 to 2.0 x 109/L
- Repeat FBC in 1 to 2 weeks
- If neutropenia persists for more than 6 weeks, investigate further
- Only request non-acute haematology assessment (after the other tests are performed) if the neutrophils are persistently below 1.0 x 109/L, or if other significant blood count abnormalities develop
- If the neutropenia appears stable after a few months and there are no other abnormalities, check every year for two years. After which, no further follow up is required if blood count remains stable and the patient is well
Drug-induced neutropenia
- If a drug cause is suspected, and if white blood cell count is less than 3 x 109/L or neutrophils less than 1.5 x 109/L, stop the suspected drug
- Check full blood count in one week and advise patient to seek medical attention if they become unwell or febrile
Referral Criteria
- Arrange urgent medical assessment if severe neutropenia and unwell or febrile. However, if the patient is known to the Haematology Department, contact the department directly.
- Request non-acute haematology assessment if:
- Neutrophils less than 1.0 x 109/L but well. Recommend repeat FBC after 48 hours to confirm neutropenia and assessment for reversible cause before referring
- Include copies of all bloods (FBC and Blood Film) as well as any extra tests that have been arranged
Referral Instructions
e-Referral Service Selection
- Specialty: Haematology
- Clinic Type: Not otherwise specified
- Service: DRSS-Northern-Haematology- Devon ICB- 15N
Referral Form
Pathway Group
This guideline has been signed off on behalf of NHS Devon.
Publication date: July 2016
