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Chapter 2: Cardiovascular
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Management of atrial fibrillation
Management of other arrhythmias
Drugs that prolong the QT interval
Anticoagulation prescribing guidance
Management of suspected deep vein thrombosis (DVT) and pulmonary embolism (PE)
Secondary prevention of stroke / TIA
Management of angina
Chronic heart failure guidance
Management of hypertension
Management of blood lipids
2.1 Positive inotropic drugs
2.2 Diuretics
2.3 Anti-arrhythmic drugs
2.4 Beta-adrenoceptor blocking drugs
2.5 Hypertension and heart failure
2.6 Nitrates, calcium-channel blockers, and other antianginal drugs
2.7 Sympathomimetics
2.8 Anticoagulants and protamine
2.9 Antiplatelet drugs
2.10 Stable angina, acute coronary syndromes, and fibrinolysis
2.11 Antifibrinolytic drugs and haemostatics
2.12 Lipid-regulating drugs
2.14 Miscellaneous cardiovascular preparations
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2.10 Stable angina, acute coronary syndromes, and fibrinolysis
First Line
Second Line
Specialist
Hospital Only
2.10.2 Fibrinolytic drugs
See NICE TA52 on the use of drugs for early thrombolysis in the treatment of acute myocardial infarction (October 2002)
Alteplase
- Vial 20mg, 50mg
Notes
- See NICE TA264 Alteplase for treating acute ischaemic stroke (September 2012)
Streptokinase
- Injection 1.5 million units
Tenecteplase
- Powder and solvent for solution for injection vial 5,000units, 8,000units, 10,000units
Notes
- NICE TA990: Tenecteplase (Metalyse) is recommended, within its marketing authorisation, as an option for the thrombolytic treatment of an acute ischaemic stroke in adults (July 2024):
- within 4.5 hours of the onset of stroke symptoms, and
- when intracranial haemorrhage has been excluded.
