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Chapter 2: Cardiovascular
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Management of atrial fibrillation
Management of other arrhythmias
Drugs that prolong the QT interval
Anticoagulation prescribing guidance
Management of suspected deep vein thrombosis (DVT) and pulmonary embolism (PE)
Secondary prevention of stroke / TIA
Management of angina
Chronic heart failure guidance
Management of hypertension
Management of blood lipids
2.1 Positive inotropic drugs
2.2 Diuretics
2.3 Anti-arrhythmic drugs
2.4 Beta-adrenoceptor blocking drugs
2.5 Hypertension and heart failure
2.6 Nitrates, calcium-channel blockers, and other antianginal drugs
2.7 Sympathomimetics
2.8 Anticoagulants and protamine
2.9 Antiplatelet drugs
2.10 Stable angina, acute coronary syndromes, and fibrinolysis
2.11 Antifibrinolytic drugs and haemostatics
2.12 Lipid-regulating drugs
2.14 Miscellaneous cardiovascular preparations
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2.2.2 Loop diuretics
First Line
Second Line
Specialist
Hospital Only
Furosemide
- Tablets 20mg, 40mg, 500mg (£0.67 = 40mg daily)
- Oral solution sugar free 20mg/5ml, 40mg/5ml (£15.57 = 20mg/5ml x 150ml)
- Injection 10mg/1ml (hospital only)
Indications
Dose
- Oral, initially 40mg in the morning; maintenance 20–40mg daily; resistant oedema, 80–120mg daily
Bumetanide
- Tablets 1mg, 5mg (£4.20 = 1mg daily)
Indications
Dose
- 1mg in the morning, repeated after 6–8 hours if necessary; severe cases, 5mg daily increased by 5mg every 12–24 hours according to response; Elderly, 500micrograms daily may be sufficient
Notes
- There is little evidence that bumetanide offers significant advantages over furosemide except that absorption may be more reliable in those with an oedematous GI tract.
