4.3.4 Other antidepressant drugs

  • Capsules 30mg, 60mg (£2.37 = 60mg daily)


  • Tablets 15mg, 30mg, 45mg (£1.27 = 30mg daily)
  • Oro-dispersible tablets 15mg, 30mg, 45mg (£1.45 = 30mg daily)


  • Capsules m/r 75mg, 150mg, 225mg (£2.60 = 75mg daily)
  • Tablets m/r 37.5mg (£12.32 = 75mg daily)
  • Tablets 37.5mg, 75mg (£1.09 = 75mg daily)



  1. Updated prescribing advice for venlafaxine (MHRA, 2014)
    1. specialist supervision is needed for severely depressed or hospitalised patients who require venlafaxine doses of 300 mg daily or more
    2. cardiac contra-indications are more targeted towards high-risk groups
    3. as previously, patients with uncontrolled hypertension should not take venlafaxine, and blood pressure monitoring is recommended for all patients
    4. concomitant SSRI use should be restricted to specialist use
    5. other drug interactions are a possibility, particularly CYP3A4 inhibitors and CYP2D6 inhibitors
    6. these interacting drugs should only be prescribed when strictly indicated
    7. when doses of 225mg are required, it is more cost-efficient to prescribe M/R capsules as 1 x 75mg + 1 x 150mg or as 3 x 75mg. If patients are unable or unwilling to use multiple capsules, prescribing as Vensir XL® 225mg capsules is most cost-efficient.


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