Formulary

Management of community multidrug-resistant (MDR) urinary tract infection (UTI)

First Line
Second Line
Specialist
Hospital Only
If released on a urine sensitivity report then consider the following i.e. not for empirical use
Pivmecillinam
  • Initially 400mg for one dose, then 200mg every 8 hours for 3 days in women, 7 days in men
  • This is an extended-spectrum penicillin antibiotic
If high risk of resistance
Fosfomycin
  • Female: 3g sachet as a single dose (dose may be repeated in complicated UTI; unlicensed)
  • Male: 3g sachet initial dose and repeat after 3 days (unlicensed but in line with PHE guidance)
  • Doses should be taken preferably before bedtime and after emptying the bladder